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Review Article

星状胶质连接蛋白在神经和神经心理疾病和辐射暴露中的作用

卷 28, 期 10, 2021

发表于: 10 June, 2020

页: [1970 - 1986] 页: 17

弟呕挨: 10.2174/0929867327666200610175037

价格: $65

摘要

放射治疗是脑和脊髓肿瘤的常见治疗方法，也是脑神经病理改变导致不同神经和神经心理障碍的危险因素。星状胶质连接蛋白与脑部炎症、阿尔茨海默病(AD)的发展、抑郁、癫痫和肌萎缩性侧索硬化症有关，并受辐射照射的影响。因此，推测辐射诱导的星形胶质连接蛋白的变化可能与脑神经病理及神经心理障碍的发生发展有关。本文就星状胶质细胞与不同类型脑细胞(包括少突胶质细胞、小胶质细胞、神经元和内皮细胞)之间星状胶质细胞连接素的功能表达和调控进行综述。这些连接素在AD、抑郁、癫痫、肌萎缩性侧索硬化症和脑炎症发生中的作用也被总结。然后讨论辐射诱导的星形胶质连接蛋白在不同神经和神经心理疾病中的变化和发展。基于现有的数据，我们认为辐射诱导的星状胶质连接蛋白的变化可能参与了不同神经和神经心理疾病的发生，这些疾病取决于年龄、脑区域和辐射剂量/剂量率。异常的星状胶质连接蛋白可能是预防辐射诱导的认知障碍、神经和心理障碍的新的治疗靶点。

关键词: 阿尔茨海默病(AD)，星状胶质连接蛋白，脑细胞，神经障碍，神经心理障碍，辐射暴露

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