Title:The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review
Volume: 19
Issue: 1
Author(s): Mohammad Zamanian, Gholamreza Bazmandegan, Antoni Sureda, Eduardo Sobarzo-Sanchez, Hasan Yousefi-Manesh and Samira Shirooie*
Affiliation:
- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah,Iran
Keywords:
Troxerutin, flavonoids, inflammation, antioxidant, natural product, neurodegeneration.
Abstract: Troxerutin (TRX), a semi-synthetic bioflavonoid derived from rutin, has been reported to
exert several pharmacological effects including antioxidant, anti-inflammatory, antihyperlipidemic,
and nephroprotective. However, the related molecular details and its mechanisms remain poorly
understood. In the present review, we presented evidences from the diversity in vitro and in vivo
studies on the therapeutic potential of TRX against neurodegenerative, diabetes, cancer and cardiovascular
diseases with the purpose to find molecular pathways related to the treatment efficacy.
TRX has a beneficial role in many diseases through multiple mechanisms including, increasing
antioxidant enzymes and reducing oxidative damage, decreasing in proapoptotic proteins (APAF-1,
BAX, caspases-9 and-3) and increasing the antiapoptotic BCL-2, increasing the nuclear translocation
of nuclear factor erythroid 2-related factor 2 (Nrf2) and downregulating the nuclear factor κB
(NFκ). TRX also reduces acetylcholinesterase activity and upregulates phosphoinositide 3-
kinase/Akt signaling pathway in Alzheimer’s disease models. Natural products such as TRX may
develop numerous and intracellular pathways at several steps in the treatment of many diseases.
Molecular mechanisms of action are revealing novel, possible combinational beneficial approaches
to treat multiple pathological conditions.
