Title:Application of Nanomaterials in Regulating the Fate of Adipose-derived Stem Cells
Volume: 16
Issue: 1
Author(s): Lang Wang, Yong Li, Maorui Zhang, Kui Huang, Shuanglin Peng and Jingang Xiao*
Affiliation:
- Department of Oral and Maxillofacial Surgery, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou 646000,China
Keywords:
Adipose-derived stem cells, nanomaterials, differentiation, biocompatibility, extracellular microenvironment,
regeneration.
Abstract: Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent.
Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly
important role in the field of tissue repair, regeneration and reconstruction. The physicochemical
properties of the extracellular microenvironment contribute to the regulation of the fate of stem cells.
Nanomaterials have stable particle size, large specific surface area and good biocompatibility, which
has led them being recognized as having broad application prospects in the field of biomedicine. In this
paper, we review recent developments of nanomaterials in adipose-derived stem cell research. Taken
together, the current literature indicates that nanomaterials can regulate the proliferation and differentiation
of adipose-derived stem cells. However, the properties and regulatory effects of nanomaterials
can vary widely depending on their composition. This review aims to provide a comprehensive guide
for future stem-cell research on the use of nanomaterials.