Title:Hyaluronic Acid and Regenerative Medicine: New Insights into the Stroke Therapy
Volume: 20
Issue: 9
Author(s): Maryam Shahi, Daruosh Mohammadnejad, Mohammad Karimipour, Seyed Hossein Rasta, Reza Rahbarghazi and Ali Abedelahi*
Affiliation:
- Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz,Iran
Keywords:
Stroke, extracellular matrix, hyaluronic acid, regenerative medicine, therapy, central nervous system.
Abstract: Stroke is known as one of the very important public health problems that are related to
societal burden and tremendous economic losses. It has been shown that there are few therapeutic
approaches for the treatment of this disease. In this regard, the present therapeutic platforms aim to
obtain neuroprotection, reperfusion, and neuro recovery. Among these therapies, regenerative
medicine-based therapies have appeared as new ways of stroke therapy. Hyaluronic acid (HA) is a
new candidate, which could be applied as a regenerative medicine-based therapy in the treatment
of stroke. HA is a glycosaminoglycan composed of disaccharide repeating elements (N-acetyl-Dglucosamine
and D-glucuronic acid). Multiple lines of evidence demonstrated that HA has critical
roles in normal tissues. It can be a key player in different physiological and pathophysiological
conditions such as water homeostasis, multiple drug resistance, inflammatory processes,
tumorigenesis, angiogenesis, and changed viscoelasticity of the extracellular matrix. HA has very
important physicochemical properties i.e., availability of reactive functional groups and its solubility,
which make it a biocompatible material for application in regenerative medicine. Given that HAbased
bioscaffolds and biomaterials do not induce inflammation or allergies and are hydrophilic,
they are used as soft tissue fillers and injectable dermal fillers. Several studies indicated that HA
could be employed as a new therapeutic candidate in the treatment of stroke. These studies
documented that HA and HA-based therapies exert their pharmacological effects via affecting
stroke-related processes. Herein, we summarized the role of the extracellular matrix in stroke
pathogenesis. Moreover, we highlighted the HA-based therapies for the treatment of stroke.
