Title:Challenges with Wound Infection Models in Drug Development
Volume: 21
Issue: 13
关键词:
感染模型、创面愈合、药物开发、抗感染药物、体内模型、体外模型
摘要:
Wound research is an evolving science trying to unfold the complex untold mechanisms
behind the wound healing cascade. In particular, interest is growing regarding the role of microorganisms
in both acute and chronic wound healing. Microbial burden plays an important role in the persistence
of chronic wounds, ultimately resulting in delayed wound healing. It is therefore important for
clinicians to understand the evolution of infection science and its various etiologies. Therefore, to understand
the role of bacterial biofilm in chronic wound pathogenesis, various in vitro and in vivo models
are required to investigate biofilms in wound-like settings. Infection models should be refined
comprising an important signet of biofilms. These models are eminent for translational research to obtain
data for designing an improved wound care formulation. However, all the existing models possess
limitations and do not fit properly in the model frame for developing wound care agents. Among various
impediments, one of the major drawbacks of such models is that the wound they possess does not
mimic the wound a human develops. Therefore, a novel wound infection model is required which can
imitate the human wounds.
This review article mainly discusses various in vitro and in vivo models showing microbial colonization,
their advantages and challenges. Apart from these models, there are also present ex vivo wound
infection models, but this review mainly focused on various in vitro and in vivo models available for
studying wound infection in controlled conditions. This information might be useful in designing an
ideal wound infection model for developing an effective wound healing formulation.
