Title:Predictive Role of BNP/NT-proBNP in Non-Heart Failure Patients Undergoing Catheter Ablation for Atrial Fibrillation: An Updated Systematic Review
Volume: 27
Issue: 27
Author(s): Nikolaos Papageorgiou *, Rui Providência, Debbie Falconer, Tanakal Wongwarawipat, Dimitris Tousoulis, Wei Yao Lim , Anthony W. Chow, Richard J. Schilling and Pier D. Lambiase
Affiliation:
- Electrophysiology Department, Barts Heart Centre, St. Bartholomew’s Hospital, West Smithfield, London EC1A 7BE,United Kingdom
Keywords:
Atrial Fibrillation (AF), ablation, Brain Natriuretic Peptide (BNP), N-terminal BNP, catheter ablation,
recurrence.
Abstract:
Atrial Fibrillation (AF) is a growing public health issue, associated with significant morbidity
and mortality. In addition to pharmacological therapy, catheter ablation is an effective strategy in
restoring and maintaining sinus rhythm. However, ablation is not without risk, and AF recurs in a significant
proportion of patients. Non-invasive, easily accessible markers or indices that could stratify
patients depending on the likelihood of a successful outcome following ablation would allow us to
select the most appropriate patients for the procedure, reducing the AF recurrence rate and exposure to
potentially life-threatening risks.
There has been much attention paid to Brain Natriuretic Peptide (BNP) and N-Terminal prohormone of
Brain Natriuretic Peptide (NT-proBNP) as possible predictive markers of successful ablation. Several
studies have demonstrated an association between higher pre-ablation levels of these peptides, and a
greater likelihood of AF recurrence. Therefore, there may be a role for measuring brain natriuretic peptides
levels when selecting patients for catheter ablation.