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Review Article

汞暴露，表观遗传学改变和脑肿瘤发生：可能的关系？

卷 27, 期 39, 2020

页: [6596 - 6610] 页: 15

弟呕挨: 10.2174/0929867326666190930150159

价格: $65

摘要

野生动植物和人类中汞（Hg）的风险评估都代表着日益严峻的挑战。活性氧（ROS）产量的增加是已知的汞诱导的毒性作用，其他环境污染物以及环境和遗传因素之间的复杂相互作用会加剧这种活性。一些流行病学和实验研究已经研究了脑肿瘤和重金属之间的可能相关性。脑肿瘤的表观遗传修饰包括基因异常激活，特定基因的低甲基化，各种组蛋白的变化以及CpG甲基化。此外，汞会降低硒的生物利用度并诱导活性氧的生成，而活性氧在不同的病理过程中起着重要的作用。金属的修饰会诱导过量的ROS，并引起脂质过氧化，蛋白质改变和DNA损伤。在这篇综述中，我们强调了汞暴露，表观遗传学改变和脑肿瘤之间的可能关系。

关键词: 汞，癌症，大脑，活性氧，体内稳态，CpG甲基化过度。

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