Title:Analysis of Unusual Adverse Effects After Radium-223 Dichloride Administration
Volume: 13
Issue: 2
Author(s): Viviana Frantellizzi*, Mariano Pontico, Arianna Pani, Roberto Pani and Giuseppe De Vincentis
Affiliation:
- Department of Molecular Medicine, Sapienza University of Rome, Rome,Italy
Keywords:
Ra-223 dichloride, alpha particle therapy, lymphedema, life quality, radiopharmaceutical adverse effects.
Abstract:
Background: To our knowledge, no previous study or literature review has been performed
about the effects of the extravasation of therapeutic radiopharmaceutical agents and its potential consequences,
especially regarding alpha-particle emitting radiopharmaceuticals.
Methods: Even if Radium-223 dichloride is known to be a relatively safe drug to manage, despite the
correctness of the procedures applied , unexpected delayed adverse effects can occur.
In our vast experience, we rarely observed lymphedema, even after some time, at the site of administration.
Results: Management of lymphedema caused by radiopharmaceuticals administration has been addressed
through clinical examples. The sudden intervention allowed a fast remission of the signs and
symptoms complained by patients treated with Radium-223 dichloride.
Conclusion: The management of adverse effects after radiopharmaceuticals administration as in case
of lymphedema onset, is extremely simple. These data confirm the safety of Radium-223 treatment.
